TOZAAR 50mg 30s TABLET
ZMK 187.00
Includes all taxes
Item requires a valid prescription
Manufactured By: TORRENT
Composition: Losartan 50mg
Hypertension
Uses / Indications:
It is used in Treatment of essential hypertension in adults and in children and adolescents 6-18 years of age. Treatment of renal disease in adult patients with hypertension and type 2 diabetes mellitus with proteinuria ≥0.5 g/day as part of an antihypertensive treatment. Treatment of chronic heart failure in adult patients when treatment with Angiotensin converting enzyme (ACE) inhibitors is not considered suitable due to incompatibility, especially cough, or contraindication.
Side Effects:
Common side effects are dizziness, vertigo, hyperkalemia, asthenia/fatigue, hypotension, including orthostatic hypotension (including dose related effects), anaemia, increase in blood urea, serum creatinine and serum potassium, renal impairment, renal failure.
How to use:
The usual starting and maintenance dose for hypertension is 50 mg once daily for most patients. The maximal antihypertensive effect is attained 3-6 weeks after initiation of therapy. Some patients may receive an additional benefit by increasing the dose to 100 mg once daily. The usual starting dose for Hypertensive type II diabetic patients with proteinuria ? 0.5 g/day is 50 mg once daily. The dose may be increased to 100 mg once daily based on blood pressure response from one month onwards after initiation of therapy.
How it works:
Losartan is a synthetic oral, angiotensin-II receptor (type AT1) antagonist. Angiotensin II, a potent vasoconstrictor, is the primary active hormone of the renin/angiotensin system and an important determinant of the pathophysiology of hypertension. Angiotensin II binds to the AT1 receptor found in many tissues (e.g. vascular smooth muscle, adrenal gland, kidneys and the heart) and elicits several important biological actions, including vasoconstriction and the release of aldosterone. Angiotensin II also stimulates smooth muscle cell proliferation.
Medicine interaction:
Losartan is predominantly metabolised by cytochrome P450 (CYP) 2C9 to the active carboxy-acid metabolite. In a clinical trial it was found that fluconazole (inhibitor of CYP2C9) decreases the exposure to the active metabolite by approximately 50%. It was found that concomitant treatment of losartan with rifampicine (inducer of matabolism enzymes) gave a 40% reduction in plasma concentration of the active metabolite. As with other medicinal products that block angiotensin II or its effects, concomitant use of other medicinal products which retain potassium (e.g. potassium-sparing diuretics: amiloride, triamterene, spironolactone) or may increase potassium levels (e.g. heparin, trimethoprim-containing products), potassium supplements or salt substitutes containing potassium may lead to increases in serum potassium. Co-medication is not advisable.
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